@mischa Subway Tooter is nice for power-users with multiple accounts; I'm *really* enjoying the granular control it gives me. It is pretty ugly, tho. And the cost of that control is some things (lots of things) take multiple steps to make happen, sometimes even something as simple as "reply".

Tusky is prettier and easier, and I think they've fixed the issues they were having with notifications, but there's only single-account support.