@alyx I switched to a dvorak-inspired DAS keyboard 12 years ago and haven't regretted.
My typing speed was slow for about three weeks during when I was practicing, but after that my speed got better than before switching.
The main benefit has been less strain and pain on hands.
Now when I must type QWERTY (very rarely indeed), I'm quite slow and must concentrate, but in any case it's not impossible and all the keyboards have QWERTY letters anyway so you can always check what you are typing.
So I'd say go for it. (But choose Dvorak and not DAS, because DAS is optimised for Finnish.)
@alyx Speed gain is just reasonal to expect, when a keyboard is designed to minimise movement and delay between key presses.
@Stoori having to rebind everything for every single game and such must be annoying :)
@alyx Well that's actually a bit random point of this whole issue. You can never know in advance if a particular software uses device binded keys or soft binded keys, and different OSes behave differently on this issue too. Better to expect almost anything.
@Stoori i expect most games for windows assume QWERTY and will have to be rebound. something i'll have to explore.
@Stoori thanks for the data point
interesting that you got faster!